Association between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: a Systematic Review and Meta-Analysis

Authors

  • Fatemeh Haghighi Department of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Hossein Neamatzadeh Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Mahdieh Kamali Department of Perinatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Mahmood Noori-Shadkam Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Mahta Mazaheri Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Sedigheh Borna Maternal-Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Sedigheh Hantoushzadeh Department of Perinatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract:

Studies have indicated that thrombophilic genes polymorphisms are associated with recurrent pregnancy loss (RPL) in the Iranian population. We aimed to evaluate the precise association between thrombophilic genes polymorphisms (MTHFR C677T, MTHFR A1298C, Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G) and RPL risk in the Iranian population. PubMed, Web of Science, Google Scholar, and ISC were searched for eligible articles published up to April 1, 2017. In total, 37 case-control studies in 18 relevant publications were selected: 1,199, 1,194, 630, 830, and 955 RPL cases and 1,079, 1079, 594, 794, and 499 controls for MTHFR C677T, MTHFR A1298C,Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G, respectively. The results indicated a significant increased risk of RPL in all genetic models in the population. Also, Prothrombin G20210A and FVL G1691A as well as PAI-1 4G/5G  polymorphisms were associated with RPL risk in the Iranian population. Hence, thrombophilic genes polymorphisms are associated with an increased RPL risk in the Iranian population.

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Journal title

volume 22  issue 2

pages  78- 89

publication date 2018-03

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